Listen to what your body is telling you
Chronic Pain May Be Linked to Your Immune System.
Research shows that in many people with chronic pain, changes in the immune system's white blood cells may play a role.
The Pain Signal Test™ — one simple blood draw, usually $0 with Medicare or PPO insurance.* Developed from DNA research at a major U.S. university medical school.
- ✓One simple blood draw
- ✓Usually $0 with insurance
- ✓Peer-reviewed, published science
- ✓No more guessing or dismissal
Ready for answers about your pain?
Patients Helped
DNA Research-Based
Of Chronic Pain Cases May Involve Immune Factors
Has your doctor offered you The Pain Signal Test™?
Most patients have never heard of it. Find out if you qualify — it takes about 3 minutes.
Why Patients Choose It
Three benefits of The Pain Signal Test™
Learn More About Your Chronic Pain
Chronic pain can be difficult to understand. The Pain Signal Test™ evaluates specific biological markers that may provide additional information for eligible patients.
A Simple Blood Test
A blood test that may offer additional insights without requiring an invasive procedure.
Understand Your Next Steps
Testing may provide information to discuss with your healthcare provider and help determine whether additional evaluation or available programs may be appropriate.
The Process
Three simple steps to real answers
One Blood Draw
A single, standard, no-cost blood draw at any Quest lab near you. No special preparation required.
Precision Analysis
The science behind our blood test is based upon unique DNA genomic signatures per peer-reviewed and published University medical center science.
Your Results & Next Steps
Receive your results and review them with your doctor. Patients with a positive score may be eligible to take part in additional programs.
The Science
Peer-reviewed, published research from a major University College of Medicine suggests that an estimated 45%+ of chronic pain patients may have immune system factors involved in their pain — which The Pain Signal Test™ is designed to help identify.
The Pain Signal Test™ provides objective, science-based information for chronic pain patients. No more guessing. No more dismissal. Just 1 blood test. Developed at a major University College of Medicine, peer-reviewed and published.
Coverage varies — we check before your blood draw. Every person whose Pain Signal Test score is positive can choose to volunteer, at NO COST, in a clinical trial of a compound developed at a leading US College of Pharmacy, being studied for its effect on related symptoms.
Coverage Verified Before Your Blood Draw
I'm Ready
How do I get The Pain Signal Test™?
Are you experiencing or have you recently experienced at least two of these common symptoms? If YES, you are a good candidate for The Pain Signal Test™.
- Chronic Pain
- Chronic Fatigue
- Brain Fog
- Anxiety/Nervousness
- Feel Depressed
- Trouble Concentrating
- Have No Energy
- Difficulty Getting to Sleep
- Difficulty Staying Asleep
- Non-Restful Sleep
- Areas of Tenderness
- Diagnosed with Interstitial Cystitis
- Headaches
- Joint Aches
- Leg Cramps
- Areas of Numbness
- Do Not Feel Well
- Bladder Area Pain
- Diagnosed with Long COVID
- Urinary Frequency
How much does The Pain Signal Test™ cost?
$0*
May Be $0* for Eligible Patients
The Pain Signal Test™ may be covered by Medicare for eligible patients. Coverage is verified before testing. The Pain Signal Test™ is also an eligible expense for flexible spending accounts (HSA, HRA, FSA).
FSA & HSA Accepted: Put your pre-tax healthcare dollars toward real answers today.
You can easily use your Flexible Spending Account (FSA) or Health Savings Account (HSA) to pay for The Pain Signal Test. Don't let your funds expire — invest in DNA-based testing for your chronic pain and fatigue.
Order Your Test Today →
Safe. Secure. Sure.
The Precision Laboratory is dedicated to testing for immune system factors based upon university-developed, peer-reviewed, and published science that relies upon whole exome DNA research.
The Precision Laboratory is not only CLIA licensed. It is among the only 3% of all US laboratories which are CAP (College of American Pathologists) accredited.
What you receive with a Positive (+) Result:
Knowledge and Intervention
- 1. Objective information about immune system factors that peer-reviewed, published research from a leading University College of Medicine has linked to chronic pain.
- 2. The option to volunteer, at NO COST, in a clinical trial of a compound developed at a leading US College of Pharmacy.
Finally — real answers, and a real path forward.
Stop guessing. Find out what may be behind your pain.
Apply Now
Get Started Today
The Pain Signal Test™ — New Patient Form
Questions? Call 1-800-994-7246
Why we ask for your insurance details: Many of our patients are hard to reach by phone. By sharing your insurance information now, our team can check your coverage and approve your test right away — often without needing to call you back. Your information is kept private and secure.
Takes about 3–4 minutes. Have your insurance card handy.